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Covid-19

Biotech Company based in Washington Advances COVID-19 Treatment Trials

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Companies across the globe are working on finding treatments for COVID-19 patients, and the latest is from CytoDyn Inc. The Washington-based biotech has developed a possible COVID-19 treatment and is one step closer to nationwide distribution if clinical trials are successful.

CytoDyn Inc. announced Monday that it made an exclusive deal with the pharmaceutical company American Regent to distribute its latest product, leronlimab, by approval from the Food and Drug Administration.

Leronlimab is currently under review by the FDA as a treatment for HIV. The drug is an antibody that attaches itself to specific immune cell receptors HIV agents. Studies from CytoDyn indicated it could be effective in slowing the speed of inflammatory molecules production.

The effects of COVID-19 can cause lung complications in patients that can lead to various respiratory illnesses. CytoDyn hopes to be used soon to treat a potentially fatal condition called Acute Respiratory Distress Syndrome caused by inflammation in the lungs, as seen in several COVID-19 patients. The company announced last month it had recruited 75 patients for a Phase 2 trial studying leronlimab’s effects on COVID-19 patients with mild to moderate symptoms.

According to CytoDyn, results from 390 COVID-19 patients’ clinical trials should be complete by the end of July. The most common side effects of leronlimab in HIV trials were diarrhea, headaches, and high blood pressure, based on a National Institute for Health report. 

The World Health Organization reported there are 19 potential candidates for a COVID-19 vaccine as of July 6. 

Other forms of treatment for COVID-19 patients are still being reviewed for their efficiency from antiviral drugs to ventilators depending on the severity of symptoms in patients. 

Sources: 

  1. https://wordofhealth.com/2020/03/07/how-pharma-companies-are-fighting-against-covid-19/
  2. https://www.cytodyn.com/newsroom/press-releases/detail/446/cytodyns-leronlimab-prevents-transmission-of-shiv-in
  3. https://www.thecentersquare.com/washington/washington-based-biotech-company-advances-covid-19-treatment-trials/article_874c8308-bfb8-11ea-aefd-cba60d46adc0.html
  4. https://www.americanregent.com/
  5. https://wordofhealth.com/2020/05/14/how-does-covid-19-affect-the-lungs/
  6. https://aidsinfo.nih.gov/drugs/423/leronlimab/0/patient
  7. https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
  8. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/what-coronavirus-does-to-the-lungs
  9. https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines
  10. https://wordofhealth.com/2020/04/22/st-joseph-hospital-testing-remdesivir-on-coronavirus-patients/

Covid-19

New Study Finds Children Can Spread COVID-19 as Much as Adults

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A new study from South Korea has discovered that children between the ages of 10 and 19 can spread COVID-19 just as much as adults. The extensive study, published by the Centers For Disease Control and Prevention, states that household transmission of the virus “was high” for those between 10 and 19 years old

Household transmission rates were lower for patients aged 0 to 9. Researchers examined reports for 59,073 contacts of 5,706 coronavirus patients in South Korea between January 20 and March 27. Dr. Ashish Jha, director of the Harvard Global Health Institute, told The New York Times that this study is one of the best to date concerning the coronavirus and transmission of the disease.

The results arrive as school officials across the nation determine whether or not to reopen schools for the upcoming year. The South Korean study said that the researchers’ findings of coronavirus transmission during school reopenings emphasize the need for a time-sensitive epidemiologic study to safeguard public health policy.

The study also indicated the effectiveness of contact tracing, especially in light of future waves of SARS-CoV-2, that will rely heavily upon social distancing and personal hygiene as primary factors for preventative measures. Awareness of the role hygiene and infection control measure plays is vital to reducing the household spread, and using masks in the home for family members who are at high risk for contracting the coronavirus needs further research.

Michael Osterholm, an infectious disease expert at the University of Minnesota, told The New York Times, that there will be transmission rates of the virus if schools reopen and include that in plans for preventing and limiting the contraction of the virus. 

Sources: 

  1. https://www.health.com/syndication/children-aged-10-19-spread-coronavirus-just-as-much-as-adults-new-study-finds
  2. https://wordofhealth.com/2020/06/27/young-californians-attribute-in-coronavirus-spike/
  3. https://wwwnc.cdc.gov/eid/article/26/10/20-1315_article
  4. https://www.hsph.harvard.edu/ashish-jha/
  5. https://www.nytimes.com/2020/07/18/health/coronavirus-children-schools.html
  6. https://wordofhealth.com/2020/04/02/is-social-distancing-helping-californians/
  7. https://wordofhealth.com/2020/06/17/how-to-fix-this-type-of-n95-mask-to-limit-the-spread-of-the-coronavirus/
  8. https://www.cidrap.umn.edu/about-us/cidrap-staff/michael-t-osterholm-phd-mph

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Covid-19

Video Laryngoscope Released in the U.S. for Faster Intubation During COVID-19

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Healthcare facilities worldwide are on the front lines during the ongoing COVID-19 pandemic by providing treatment for patients. Those who are in critical condition in intensive care units need intubation, but this process can be complicated by obtaining an airway precisely. Each patient varies; some can take a minute or more during intubation, potentially leading to fatal consequences. 

Nihon Kohden is launching its NK AWS-S200 video laryngoscope in the United States under the Pentax brand outside the United States. This device is designed to achieve intubation faster and on the first try. Furthermore, the company claims the product “can help protect clinicians while intubating patients suffering from COVID-19 or other respiratory infections”.

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The NK AWS-S20 features a high-definition color display targeting cross-hairs that help deliver the working end into the airway. A functioning channel allows for the endotracheal tube to be pushed while viewing the airway properly. 

There is a built-in-channel to guide the endotracheal tube and continuously observe the intubation process. The video laryngoscope can decrease the risk of oral and pharyngeal injury, such as mild mucosal bleeding and sore throat.

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Nihon Kohden mentioned that the NK AWS-S200  allows healthcare professionals to intubate challenging patients quicker than other competitor’s devices. The company expressed the device can help clinicians intubate patients with even difficult airways in  22.9 seconds, well below the 30-second threshold suggested for intubations and up to 33 seconds faster than other devices. 

Genoveffa Devers, DNP, MSHA, RN, CPHQ, VP of clinical and strategic alliances at Nihon Kohden stated the importance of tools to establish an airway quickly and efficiently as possible for healthcare providers. She added that the NK AWS-S200 video laryngoscope is designed to attain this while maintaining clinicians’ safety by limiting contact trying to visualize the vocal cords and larynx. 

Using the firm’s disposable NK PBLADE blades, which are available in four different sizes, help clinicians reduce cross-contamination between patients and those providing treatment.

In addition, when administering CPR, the video laryngoscope can be used to intubate patients without delaying life-saving treatment. 

Sources: 

  1. https://www.medgadget.com/2020/07/nihon-kohden-releases-video-laryngoscope-in-u-s-for-faster-intubation-during-covid.html
  2. https://www.webmd.com/lung/intubation-explained
  3. https://www.nihonkohden.com/

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Covid-19

‘COVID Symptom Study’ App Tracks Various COVID-19 Symptoms

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A new smartphone COVID-19 app that tracks symptoms has gathered information from more than 4 million people worldwide and gives doctors the ability to examine the different symptoms patients are experiencing with the virus. The mixture of various symptoms people are exhibiting with COVID-19 is unexpected.

According to Dr. Troy Pennington of Arrowhead Regional Medical Center in Colton, there are various forms of COVID-19 symptoms in patients. The application is called the COVID Symptom Study, was designed by healthcare professionals and scientists at Massachusetts General Hospital, The Harvard T.H. Chan School of Public Health, King’s College London and Stanford University School of Medicine, working beside ZOE, a health science company. Users can input their health information and get statistics on those participating around their region. 

Researchers grouped patients into six different clusters. The first cluster of patients are those experiencing mild symptoms who had flu-like symptoms, according to Pennington. The symptoms included body aches, possibly a sore throat, mild shortness of breath, and mostly mild symptoms, but no fever.

The second cluster of patients displayed similar symptoms, but with a fever. The third group of patients included gastrointestinal issues. Pennington added that there was a GI component with mild diarrhea or even an upset stomach. 

The fourth cluster of patients added severe fatigue, while the fifth added confusion as part of their symptoms. The sixth cluster consisted of patients experiencing the most severe symptoms, including abdominal and respiratory problems. This group had all of the common attributes of flu-like illness, but it had a very significant GI component with persistent abdominal pain and diarrhea. 

Pennington stated some of his patients at Arrowhead Regional Medical Center had exhibited even more peculiar symptoms such as unusual rashes and rashes that also looked like hives or chickenpox. Another patient was complaining of number fingers and toes. 

According to the study, the only common symptoms in all six clusters were headaches and loss of smell.

The COVID Symptom Study app has allowed physicians to get a closer look at COVID-19 symptoms patients experience to help healthcare professionals identify and treat patients accordingly. 

Sources: 

  1. https://abc7.com/covid-19-covid-symptoms-coronavirus-is-upset-stomach-and-diarrhea-a-symptom-of/6345955/
  2. https://wordofhealth.com/2020/07/11/pink-eye-symptom-of-covid-19/
  3. https://covid.joinzoe.com/us
  4. https://wordofhealth.com/2020/05/14/how-does-covid-19-affect-the-lungs/

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